Devotions upon Emergent Occasions

Devotions upon emergent occasions

Society since its inauguration in 1660. There were several in the seventeenth and early eighteenth centuries, and the present club probably began in 1731. However, during its lifetime other subsidiary clubs have been formed: Sir Joseph Banks', The Royal Society Club, 1775 to 1784; the 47 Club, from 1874 to 1901 when it amalgamated with the older club. Naturally there have been several accounts ...

Knowing for whom the bell tolls: acting locally and thinking globally. Brazil, Latin America and the Global Burden of Diseases, 2015.

“No man is an Iland, intire of it selfe; every man is a peece of the Continent, a part of the maine; if a Clod bee washed away by the Sea, Europe is the lesse, as well as if a Promontorie were, as well as if a Mannor of thy friends or of thine owne were; any mans death diminishes me, because I am involved in Mankinde; And therefore never send to know for whom the bell tolls; It tolls for thee” ...

A proteasome for all occasions.

In the ubiquitin-proteasome system, substrates fated for destruction first acquire covalent modification by ubiquitin, and are subsequently destroyed by the proteasome. Traditionally, 26S proteasomes have been seen as largely uniform in their composition and functional capacity. Accordingly, cells can control proteasome abundance via transcriptional pathways that mediate concerted regulation of...

A Receptor for All Occasions

Cells communicate with their environment, in part, through cell surface receptors. Engineering receptors that both sense arbitrary inputs and provide outputs orthogonal to endogenous signaling pathways has been a challenge. Now, Lim and colleagues report a system based on synthetic Notch receptors that allows independent control of both inputs and outputs in diverse cell types.

Novel Devotions : Conversional Reading , Computational Modeling , and the Modern Novel